منابع مشابه
Cyclic Amp and Folic Acid Mediated Cyclic Gmp Accumulation In
In a suitable environment spores of the Dictyostelia [ 1 ] germinate yielding small amoebae. Each amoebae feeds on bacteria and divides. Following consumption of the food supply amoebae aggregate forming a slug where cells differentiate into spores and stalk ceils. The orientation of cells towards a food source or an aggregation center is guided by gradients of concentration of chemotactic mole...
متن کاملCyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.
Long-term regulation of the cyclic nucleotide phosphodiesterase of the C-6 rat glioma cell line has been studied. Both the low K(m) and high K(m) activities can be induced by elevation of intracellular cyclic AMP levels following either dibutyryl cyclic AMP or norepinephrine treatment of the cells. The enzymes are maximally induced by 3-4 hr. The presence of either cycloheximide or actinomycin ...
متن کاملReversal of cyclic AMP-mediated intestinal secretion by ethacrynic acid.
Ethacrynic acid (EA) has been reported to reduce cholera toxin-induced intestinal fluid secretion in the intact animal. We explored the nature of this inhibition in vitro by measuring unidirectional, transmural fluxes of (22)Na and (36)Cl across isolated rabbit ileal mucosa. Under control conditions (short-circuited mucosa bathed in bicarbonate-Ringer), there was net absorption of Na and Cl. Th...
متن کاملCyclic AMP mediated gene expression in bovine corneal endothelial cells.
PURPOSE Agents that increase intracellular levels of cAMP mediate gene expression associated with cellular morphology, growth, and/or differentiation via the cAMP response element (CRE). The cAMP element binding protein (CREB) is a transcriptional activator that binds and stimulates gene expression from the CRE in the promoters of cAMP responsive genes. This study was designed to characterize t...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2011
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2010.11.005